Risk characteristics of the combined geographic atrophy and choroidal neovascularisation phenotype in age-related macular degeneration.

ABSTRACT:

Aim

To investigate the risk characteristics of the combined geographic atrophy (GA) and choroidal neovascularisation (CNV) phenotype of age-related macular degeneration (AMD) compared to GA or CNV.

Methods

Patients with advanced AMD were identified and divided into three groups using multimodal imaging: patients with GA in at least one eye, patients with CNV in at least one eye, and patients with simultaneous GA and CNV in at least one eye. Epidemiologic and clinical factors were gathered from patient questionnaires. Genotypes for age-related maculopathy susceptibility 2 (ARMS2) and complement factor H (CFH) were determined.

Results

42 patients with GA or CNV, and 16 patients with combined GA/CNV were identified. Patients with the combined phenotype were older (86.4 v

SUBMITTER: Saade C 

PROVIDER: S-EPMC4233165 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature