Ontology highlight
ABSTRACT:
SUBMITTER: Watanabe M
PROVIDER: S-EPMC4233361 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20141002 11
Toll-like receptors (TLRs) play important roles in the innate immune system. In fact, recognition of endogenous immune complexes containing self-nucleic acids as pathogen- or damage-associated molecular patterns contributes to certain autoimmune diseases, and inhibition of these recognition signals is expected to have therapeutic value. We identified dihydropyrrolo[2,3-d]pyrimidines as novel selective TLR9 antagonists with high aqueous solubility. A structure-activity relationship study of a kno ...[more]