High-dose rifapentine with moxifloxacin for pulmonary tuberculosis.

ABSTRACT:

Background

Tuberculosis regimens that are shorter and simpler than the current 6-month daily regimen are needed.

Methods

We randomly assigned patients with newly diagnosed, smear-positive, drug-sensitive tuberculosis to one of three regimens: a control regimen that included 2 months of ethambutol, isoniazid, rifampicin, and pyrazinamide administered daily followed by 4 months of daily isoniazid and rifampicin; a 4-month regimen in which the isoniazid in the control regimen was replaced by moxifloxacin administered daily for 2 months followed by moxifloxacin and 900 mg of rifapentine administered twice weekly for 2 months; or a 6-month regimen in which isoniazid was replaced by daily moxifloxacin for 2 months followed by one weekly dose of both moxifloxacin and 1200 mg of rif

SUBMITTER: Jindani A 

PROVIDER: S-EPMC4233406 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature