Programming chemistry in DNA-addressable bioreactors.

ABSTRACT: We present a formal calculus, termed the chemtainer calculus, able to capture the complexity of compartmentalized reaction systems such as populations of possibly nested vesicular compartments. Compartments contain molecular cargo as well as surface markers in the form of DNA single strands. These markers serve as compartment addresses and allow for their targeted transport and fusion, thereby enabling reactions of previously separated chemicals. The overall system organization allows for the set-up of programmable chemistry in microfluidic or other automated environments. We introduce a simple sequential programming language whose instructions are motivated by state-of-the-art microfluidic technology. Our approach integrates electronic control, chemical computing and material production i

SUBMITTER: Fellermann H 

PROVIDER: S-EPMC4233719 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature