Association of BDNF Val66Met polymorphism with HPA and SAM axis reactivity to psychological and physical stress.

ABSTRACT:

Background

Decreased expression of brain-derived neurotrophic factor (BDNF) is implicated in enhanced stress responses. The BDNF Val66Met polymorphism is associated with psychological changes; for example, carriers of the Met allele exhibit increased harm avoidance as well as a higher prevalence of depression and anxiety disorder.

Methods

To analyze the effects of BDNF Val66Met on stress responses, we tested 226 university students (88 women and 138 men) using a social stress procedure (Trier Social Stress Test [TSST]) and an electrical stimulation stress test. Stress indices were derived from repeated measurements of salivary α-amylase, salivary cortisol, heart rate, and psychological testing during the stress tests. All subjects were genotyped for the Val66Met polymorphism

SUBMITTER: Tsuru J 

PROVIDER: S-EPMC4234157 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature