A Phase II trial of a combination herbal supplement for men with biochemically recurrent prostate cancer.

ABSTRACT:

Background

Men with biochemical recurrence (BCR) of prostate cancer are typically observed or treated with androgen-deprivation therapy. Non-hormonal, non-toxic treatments to slow the rise of PSA are desirable. We studied a combination herbal supplement, Prostate Health Cocktail (PHC), in prostate cancer cell lines and in a population of men with BCR.

Methods

PC3, LAPC3 and LNCaP cells were incubated with increasing concentrations of PHC suspension. Men previously treated for prostate cancer with surgery, radiation or both with rising PSA but no radiographic metastases were treated with three capsules of PHC daily; the primary end point was 50% PSA decline. Circulating tumor cells (CTCs) were identified using parylene membrane filters.

Results

PHC showed a strong dose

SUBMITTER: Dorff TB 

PROVIDER: S-EPMC4234307 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature