Arabidopsis mTERF15 is required for mitochondrial nad2 intron 3 splicing and functional complex I activity.

ABSTRACT: Mitochondria play a pivotal role in most eukaryotic cells, as they are responsible for the generation of energy and diverse metabolic intermediates for many cellular events. During endosymbiosis, approximately 99% of the genes encoded by the mitochondrial genome were transferred into the host nucleus, and mitochondria import more than 1000 nuclear-encoded proteins from the cytosol to maintain structural integrity and fundamental functions, including DNA replication, mRNA transcription and RNA metabolism of dozens of mitochondrial genes. In metazoans, a family of nuclear-encoded proteins called the mitochondrial transcription termination factors (mTERFs) regulates mitochondrial transcription, including transcriptional termination and initiation, via their DNA-binding activities, and the dys

SUBMITTER: Hsu YW 

PROVIDER: S-EPMC4234379 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature