The effects of comorbidity on the benefits and harms of treatment for chronic disease: a systematic review.

ABSTRACT:

Background

There are concerns about the potential for unintentional harms when clinical practice guidelines are applied to patients with multimorbidity. The objective was to summarize the evidence regarding the effect(s) of comorbidity on the outcomes of medication for an index chronic condition.

Methods

A systematic review was conducted of studies published in MEDLINE and Cochrane Trials before May 2012. The search strategy was constructed to identify articles indexed with "comorbidity" or a related term or by a given condition and one or more additional specified comorbid conditions. The search yielded 3252 articles, of which 37 passed the title/abstract screening process, and 22 were included after full-text review. An additional 23 articles were identified by screening t

SUBMITTER: Fried TR 

PROVIDER: S-EPMC4234418 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature