MtDNA haplogroup and single nucleotide polymorphisms structure human microbiome communities.

ABSTRACT:

Background

Although our microbial community and genomes (the human microbiome) outnumber our genome by several orders of magnitude, to what extent the human host genetic complement informs the microbiota composition is not clear. The Human Microbiome Project (HMP) Consortium established a unique population-scale framework with which to characterize the relationship of microbial community structure with their human hosts. A wide variety of taxa and metabolic pathways have been shown to be differentially distributed by virtue of race/ethnicity in the HMP. Given that mtDNA haplogroups are the maternally derived ancestral genomic markers and mitochondria's role as the generator for cellular ATP, characterizing the relationship between human mtDNA genomic variants and microbiome profile

SUBMITTER: Ma J 

PROVIDER: S-EPMC4234434 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature