Genome-wide copy number variant discovery in dogs using the CanineHD genotyping array.

ABSTRACT:

Background

Substantial contribution to phenotypic diversity is accounted for by copy number variants (CNV). In human, as well as other species, the effect of CNVs range from benign to directly disease-causing which motivates the continued investigations of CNVs. Previous canine genome-wide screenings for CNVs have been performed using high-resolution comparative genomic hybridisation arrays which have contributed with a detailed catalogue of CNVs. Here, we present the first CNV investigation in dogs based on the recently reported CanineHD 170 K genotyping array. The hitherto largest dataset in canine CNV discovery was assessed, 351 dogs from 30 different breeds, enabling identification of novel CNVs and a thorough characterisation of breed-specific CNVs.

Results

A stringent

SUBMITTER: Molin AM 

PROVIDER: S-EPMC4234435 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature