Urinary calprotectin and posttransplant renal allograft injury.

ABSTRACT:

Objective

Current methods do not predict the acute renal allograft injury immediately after kidney transplantation. We evaluated the diagnostic performance of urinary calprotectin for predicting immediate posttransplant allograft injury.

Methods

In a multicenter, prospective-cohort study of 144 incipient renal transplant recipients, we postoperatively measured urinary calprotectin using an enzyme-linked immunosorbent assay and estimated glomerular filtration rate (eGFR) after 4 weeks, 6 months, and 12 months.

Results

We observed a significant inverse association of urinary calprotectin concentrations and eGFR 4 weeks after transplantation (Spearman r =  -0.33; P<0.001). Compared to the lowest quartile, patients in the highest quartile of urinary calprotectin had an in

SUBMITTER: Tepel M 

PROVIDER: S-EPMC4234472 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature