Implications of human genome structural heterogeneity: functionally related genes tend to reside in organizationally similar genomic regions.

ABSTRACT:

Background

In an earlier study, we hypothesized that genomic segments with different sequence organization patterns (OPs) might display functional specificity despite their similar GC content. Here we tested this hypothesis by dividing the human genome into 100 kb segments, classifying these segments into five compositional groups according to GC content, and then characterizing each segment within the five groups by oligonucleotide counting (k-mer analysis; also referred to as compositional spectrum analysis, or CSA), to examine the distribution of sequence OPs in the segments. We performed the CSA on the entire DNA, i.e., its coding and non-coding parts the latter being much more abundant in the genome than the former.

Results

We identified 38 OP-type clusters of segments

SUBMITTER: Paz A 

PROVIDER: S-EPMC4234528 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature