Mechanistic stochastic model of histone modification pattern formation.

ABSTRACT:

Background

The activity of a single gene is influenced by the composition of the chromatin in which it is embedded. Nucleosome turnover, conformational dynamics, and covalent histone modifications each induce changes in the structure of chromatin and its affinity for regulatory proteins. The dynamics of histone modifications and the persistence of modification patterns for long periods are still largely unknown.

Results

In this study, we present a stochastic mathematical model that describes the molecular mechanisms of histone modification pattern formation along a single gene, with non-phenomenological, physical parameters. We find that diffusion and recruitment properties of histone modifying enzymes together with chromatin connectivity allow for a rich repertoire of stoch

SUBMITTER: Anink-Groenen LC 

PROVIDER: S-EPMC4234852 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature