A multi-level multi-scale approach to study essential genes in Mycobacterium tuberculosis.

ABSTRACT:

Background

The set of indispensable genes that are required by an organism to grow and sustain life are termed as essential genes. There is a strong interest in identification of the set of essential genes, particularly in pathogens, not only for a better understanding of the pathogen biology, but also for identifying drug targets and the minimal gene set for the organism. Essentiality is inherently a systems property and requires consideration of the system as a whole for their identification. The available experimental approaches capture some aspects but each method comes with its own limitations. Moreover, they do not explain the basis for essentiality in most cases. A powerful prediction method to recognize this gene pool including rationalization of the known essential genes i

SUBMITTER: Ghosh S 

PROVIDER: S-EPMC4234997 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature