The precise timeline of transcriptional regulation reveals causation in mouse somitogenesis network.

ABSTRACT:

Background

In vertebrate development, the segmental pattern of the body axis is established as somites, masses of mesoderm distributed along the two sides of the neural tube, are formed sequentially in the anterior-posterior axis. This mechanism depends on waves of gene expression associated with the Notch, Fgf and Wnt pathways. The underlying transcriptional regulation has been studied by whole-transcriptome mRNA profiling; however, interpretation of the results is limited by poor resolution, noisy data, small sample size and by the absence of a wall clock to assign exact time for recorded points.

Results

We present a method of Maximum Entropy deconvolution in both space and time and apply it to extract, from microarray timecourse data, the full spatiotemporal expression pr

SUBMITTER: Fongang B 

PROVIDER: S-EPMC4235037 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature