A profile of transcriptomic changes in the rd10 mouse model of retinitis pigmentosa.

ABSTRACT:

Purpose

Retinitis pigmentosa (RP) is a photoreceptor disease that affects approximately 100,000 people in the United States. Treatment options are limited, and the prognosis for most patients is progressive vision loss. Unfortunately, understanding of the molecular underpinnings of RP initiation and progression is still limited. However, the development of animal models of RP, coupled with high-throughput sequencing, has provided an opportunity to study the underlying cellular and molecular changes in this disease.

Methods

Using RNA-Seq, we present the first retinal transcriptome analysis of the rd10 murine model of retinal degeneration.

Results

Our data confirm the loss of rod-specific transcripts and the increased relative expression of Müller-specific transcripts,

SUBMITTER: Uren PJ 

PROVIDER: S-EPMC4235044 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature