Induction of apoptosis in cancer cell lines by the Red Sea brine pool bacterial extracts.

ABSTRACT:

Background

Marine microorganisms are considered to be an important source of bioactive molecules against various diseases and have great potential to increase the number of lead molecules in clinical trials. Progress in novel microbial culturing techniques as well as greater accessibility to unique oceanic habitats has placed the marine environment as a new frontier in the field of natural product drug discovery.

Methods

A total of 24 microbial extracts from deep-sea brine pools in the Red Sea have been evaluated for their anticancer potential against three human cancer cell lines. Downstream analysis of these six most potent extracts was done using various biological assays, such as Caspase-3/7 activity, mitochondrial membrane potential (MMP), PARP-1 cleavage and expression

SUBMITTER: Sagar S 

PROVIDER: S-EPMC4235048 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature