Targeting Plasmodium falciparum Hsp90: Towards Reversing Antimalarial Resistance.

ABSTRACT: Malaria continues to exact a great human toll in tropical settings. Antimalarial resistance is rife and the parasite inexorably develops mechanisms to outwit our best drugs, including the now first-line choice, artesunate. Novel strategies to circumvent resistance are needed. Here we detail drug development focusing on heat shock protein 90 and its central role as a chaperone. A growing body of evidence supports the role for Hsp90 inhibitors as adjunctive drugs able to restore susceptibility to traditionally efficacious compounds like chloroquine.

SUBMITTER: Shahinas D 

PROVIDER: S-EPMC4235713 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature