Ontology highlight
ABSTRACT:
SUBMITTER: Unternaehrer JJ
PROVIDER: S-EPMC4235745 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Stem cell reports 20141011 5
Reprogramming of fibroblasts to induced pluripotent stem cells (iPSCs) entails a mesenchymal to epithelial transition (MET). While attempting to dissect the mechanism of MET during reprogramming, we observed that knockdown (KD) of the epithelial-to-mesenchymal transition (EMT) factor SNAI1 (SNAIL) paradoxically reduced, while overexpression enhanced, reprogramming efficiency in human cells and in mouse cells, depending on strain. We observed nuclear localization of SNAI1 at an early stage of fib ...[more]