Ontology highlight
ABSTRACT:
SUBMITTER: Wang YJ
PROVIDER: S-EPMC4236134 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
PloS one 20141118 11
The role of miRNA processing in the maintenance of adult pancreatic acinar cell identity and during the initiation and progression of pancreatic neoplasia has not been studied in detail. In this work, we deleted Dicer specifically in adult pancreatic acinar cells, with or without simultaneous activation of oncogenic Kras. We found that Dicer is essential for the maintenance of acinar cell identity. Acinar cells lacking Dicer showed increased plasticity, as evidenced by loss of polarity, initiati ...[more]