Characterization and quantification of the fungal microbiome in serial samples from individuals with cystic fibrosis.

ABSTRACT:

Background

Human-associated microbial communities include fungi, but we understand little about which fungal species are present, their relative and absolute abundances, and how antimicrobial therapy impacts fungal communities. The disease cystic fibrosis (CF) often involves chronic airway colonization by bacteria and fungi, and these infections cause irreversible lung damage. Fungi are detected more frequently in CF sputum samples upon initiation of antimicrobial therapy, and several studies have implicated the detection of fungi in sputum with worse outcomes. Thus, a more complete understanding of fungi in CF is required.

Results

We characterized the fungi and bacteria in expectorated sputa from six CF subjects. Samples were collected upon admission for systemic antibacter

SUBMITTER: Willger SD 

PROVIDER: S-EPMC4236224 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature