Divergent mitochondrial biogenesis responses in human cardiomyopathy.

ABSTRACT:

Background

Mitochondria are key players in the development and progression of heart failure (HF). Mitochondrial (mt) dysfunction leads to diminished energy production and increased cell death contributing to the progression of left ventricular failure. The fundamental mechanisms that underlie mt dysfunction in HF have not been fully elucidated.

Methods and results

To characterize mt morphology, biogenesis, and genomic integrity in human HF, we investigated left ventricular tissue from nonfailing hearts and end-stage ischemic (ICM) or dilated (DCM) cardiomyopathic hearts. Although mt dysfunction was present in both types of cardiomyopathy, mt were smaller and increased in number in DCM compared with ICM or nonfailing hearts. mt volume density and mtDNA copy number was increas

SUBMITTER: Ahuja P 

PROVIDER: S-EPMC4236313 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature