Evolution of context dependent regulation by expansion of feast/famine regulatory proteins.

ABSTRACT:

Background

Expansion of transcription factors is believed to have played a crucial role in evolution of all organisms by enabling them to deal with dynamic environments and colonize new environments. We investigated how the expansion of the Feast/Famine Regulatory Protein (FFRP) or Lrp-like proteins into an eight-member family in Halobacterium salinarum NRC-1 has aided in niche-adaptation of this archaeon to a complex and dynamically changing hypersaline environment.

Results

We mapped genome-wide binding locations for all eight FFRPs, investigated their preference for binding different effector molecules, and identified the contexts in which they act by analyzing transcriptional responses across 35 growth conditions that mimic different environmental and nutritional conditio

SUBMITTER: Plaisier CL 

PROVIDER: S-EPMC4236453 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature