Association study of two inflammation-related polymorphisms with susceptibility to hepatocellular carcinoma: a meta-analysis.

ABSTRACT:

Background

Inflammation is a response of body tissues to injury or irritation. Small RNAs, such as miR-146a and miR-499, participate in various processes of tumorigenesis. A recent study indicates that inflammation and abnormal immune responses may promote malignant progression in cancer development, indicating that inflammation-related polymorphisms such as miR-146a rs2910164 and miR-499 rs3746444 are crucial. However, studies on the association of these two polymorphisms with hepatocellular carcinoma (HCC) are inconclusive and inconsistent. We aimed at accessing the combined result of reported studies and make a more precise estimate of the relationship.

Methods

Meta-analysis was performed on the associations between the miR-146a rs2910164 C > G and miR-499 rs3746444 T > C

SUBMITTER: Liu J 

PROVIDER: S-EPMC4236519 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature