Phylogenomic analysis of glycogen branching and debranching enzymatic duo.

ABSTRACT:

Background

Branched polymers of glucose are universally used for energy storage in cells, taking the form of glycogen in animals, fungi, Bacteria, and Archaea, and of amylopectin in plants. Some enzymes involved in glycogen and amylopectin metabolism are similarly conserved in all forms of life, but some, interestingly, are not. In this paper we focus on the phylogeny of glycogen branching and debranching enzymes, respectively involved in introducing and removing of the α(1-6) bonds in glucose polymers, bonds that provide the unique branching structure to glucose polymers.

Results

We performed a large-scale phylogenomic analysis of branching and debranching enzymes in over 400 completely sequenced genomes, including more than 200 from eukaryotes. We show that branching and d

SUBMITTER: Zmasek CM 

PROVIDER: S-EPMC4236520 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature