Genetic variants of the vitamin K dependent coagulation system and intraventricular hemorrhage in preterm infants.

ABSTRACT:

Background

Pathogenesis of intraventricular hemorrhage (IVH) in premature infants is multifactorial. Little is known about the impact of genetic variants in the vitamin K-dependent coagulation system on the development of IVH.

Methods

Polymorphisms in the genes encoding vitamin K epoxide reductase complex 1 (VKORC1 -1639G>A) and coagulation factor 7 (F7 -323Ins10) were examined prospectively in 90 preterm infants <32 weeks gestational age with respect to coagulation profile and IVH risk.

Results

F7-323Ins10 was associated with lower factor VII levels, but not with individual IVH risk. In VKORC1-wildtype infants, logistic regression analysis revealed a higher IVH risk compared to carriers of the -1639A allele. Levels of the vitamin K-dependent coagulation parameters as

SUBMITTER: Schreiner C 

PROVIDER: S-EPMC4236669 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature