Proteomics-based metabolic modeling and characterization of the cellulolytic bacterium Thermobifida fusca.

ABSTRACT:

Background

Thermobifida fusca is a cellulolytic bacterium with potential to be used as a platform organism for sustainable industrial production of biofuels, pharmaceutical ingredients and other bioprocesses due to its capability of potential to convert plant biomass to value-added chemicals. To best develop T. fusca as a bioprocess organism, it is important to understand its native cellular processes. In the current study, we characterize the metabolic network of T. fusca through reconstruction of a genome-scale metabolic model and proteomics data. The overall goal of this study was to use multiple metabolic models generated by different methods and comparison to experimental data to gain a high-confidence understanding of the T. fusca metabolic network.

Results

We report t

SUBMITTER: Vanee N 

PROVIDER: S-EPMC4236713 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature