Network features suggest new hepatocellular carcinoma treatment strategies.

ABSTRACT:

Background

Resistance to therapy remains a major cause of the failure of cancer treatment. A major challenge in cancer therapy is to design treatment strategies that circumvent the higher-level homeostatic functions of the robust cellular network that occurs in resistant cells. There is a lack of understanding of mechanisms responsible for the development of cancer and the basis of therapy-resistance mechanisms. Cellular signaling networks have an underlying architecture guided by universal principles. A robust system, such as cancer, has the fundamental ability to survive toxic anticancer drug treatments or a stressful environment mainly due to its mechanisms of redundancy. Consequently, inhibition of a single component/pathway would probably not constitute a successful cancer the

SUBMITTER: Lavi O 

PROVIDER: S-EPMC4236726 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature