Changes in the cellular proteins of A549 infected with hepatitis E virus by proteomics analysis.

ABSTRACT:

Background

Our understanding of Hepatitis E virus (HEV) has changed enormously over the past 30 years, from a waterborne infection causing outbreaks of acute hepatitis in developing countries to an infection of global distribution causing a range of hepatic and extra-hepatic illness. However, the key proteins playing important parts in the virus infection were still unknown. Understanding the changes of cellular proteins in these cells exposed to HEV is helpful for elucidating molecular mechanisms associated with function alterations of HEV-infected susceptible cells. In the present study, a comparative gel-based proteomic analysis was employed to study the changes in cellular proteins of A549 exposed to HEV in vitro to provide novel information for understanding the functional alt

SUBMITTER: Shen Q 

PROVIDER: S-EPMC4236826 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature