Antiretroviral-free HIV-1 remission and viral rebound after allogeneic stem cell transplantation: report of 2 cases.

ABSTRACT:

Background

It is unknown whether the reduction in HIV-1 reservoirs seen after allogeneic hematopoietic stem cell transplantation (HSCT) with susceptible donor cells is sufficient to achieve sustained HIV-1 remission.

Objective

To characterize HIV-1 reservoirs in blood and tissues and perform analytic antiretroviral treatment interruptions to determine the potential for allogeneic HSCT to lead to sustained, antiretroviral-free HIV-1 remission.

Design

Case report with characterization of HIV-1 reservoirs and immunity before and after antiretroviral interruption.

Setting

Tertiary care center.

Patients

Two men with HIV with undetectable HIV-1 after allogeneic HSCT for hematologic tumors.

Measurements

Quantification of HIV-1 in various tissues after HS

SUBMITTER: Henrich TJ 

PROVIDER: S-EPMC4236912 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature