Ontology highlight
ABSTRACT:
SUBMITTER: Cai F
PROVIDER: S-EPMC4237501 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
PloS one 20141119 11
Protein ubiquitinylation regulates protein stability and activity. RAD6, an E2 ubiquitin-conjugating enzyme, which that has been substantially biochemically characterized, functions in a number of biologically relevant pathways, including cell cycle progression. In this study, we show that RAD6 promotes the G1-S transition and cell proliferation by regulating the expression of cyclin D1 (CCND1) in human cells. Furthermore, our data indicate that RAD6 influences the transcription of CCND1 by incr ...[more]