Plasma matrix metalloproteinase 1, 3, and 7 levels and breast cancer risk in the Nurses' Health study.

ABSTRACT:

Purpose

Matrix metalloproteinases (MMPs), in particular MMP1, 3, and 7, are believed to be critical to breast cancer invasion and metastasis and also may have important functions earlier in breast carcinogenesis. However, the relationship between circulating levels of MMP1, 3, and 7 and breast cancer risk is uncertain.

Methods

We examined associations between plasma MMP1, 3, and 7 and breast cancer risk in a prospective case-control study nested within the Nurses' Health Study. Blood samples were collected from 801 cases who developed breast cancer between 1992 and 2000 and 801 matched controls, and MMP levels were measured via immunofluorescence assay.

Results

No overall association was observed between any of these MMPs and breast cancer risk [top vs. bottom quintil

SUBMITTER: Aroner SA 

PROVIDER: S-EPMC4237657 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature