Association of the ST3GAL4 rs11220462 polymorphism and serum lipid levels in the Mulao and Han populations.

ABSTRACT:

Background

A previous genome-wide association study has displayed the association of the ST3 beta-galactoside alpha-2,3-sialytransferase 4 (ST3GAL4) gene variant and lipid traits in the individuals of European ancestry, but the reproducibility of this association has not been detected in the Chinese population. The present study was undertaken to detect the association of ST3GAL4 rs11220462 single nucleotide polymorphism (SNP) and several environmental factors with serum lipid profiles in the Mulao and Han populations.

Methods

A total of 700 unrelated individuals of Mulao nationality and 694 subjects of Han nationality were randomly selected from our previous stratified randomized samples. Genotypes of the SNP were determined via polymerase chain reaction and restriction fra

SUBMITTER: Lin QZ 

PROVIDER: S-EPMC4237880 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature