A Rb1 promoter variant with reduced activity contributes to osteosarcoma susceptibility in irradiated mice.

ABSTRACT:

Background

Syndromic forms of osteosarcoma (OS) account for less than 10% of all recorded cases of this malignancy. An individual OS predisposition is also possible by the inheritance of low penetrance alleles of tumor susceptibility genes, usually without evidence of a syndromic condition. Genetic variants involved in such a non-syndromic form of tumor predisposition are difficult to identify, given the low incidence of osteosarcoma cases and the genetic heterogeneity of patients. We recently mapped a major OS susceptibility QTL to mouse chromosome 14 by comparing alpha-radiation induced osteosarcoma in mouse strains which differ in their tumor susceptibility.

Methods

Tumor-specific allelic losses in murine osteosacoma were mapped along chromosome 14 using microsatellite ma

SUBMITTER: Rosemann M 

PROVIDER: S-EPMC4237942 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature