Rationale and design of the Vitamin D and Type 2 Diabetes (D2d) study: a diabetes prevention trial.

ABSTRACT:

Objective

Observational studies suggest that vitamin D may lower the risk of type 2 diabetes. However, data from long-term trials are lacking. The Vitamin D and Type 2 Diabetes (D2d) study is a randomized clinical trial designed to examine whether a causal relationship exists between vitamin D supplementation and the development of diabetes in people at high risk for type 2 diabetes.

Research design and methods

D2d was designed with support from a U34 planning grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The final protocol was approved by the D2d Research Group, the data and safety monitoring board, and NIDDK. Key eligibility criteria are age ≥30 years, BMI of 24 (22.5 for Asian Americans) to 42 kg/m(2), increased risk for diabetes

SUBMITTER: Pittas AG 

PROVIDER: S-EPMC4237973 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature