Caveolin-1 expression and cavin stability regulate caveolae dynamics in adipocyte lipid store fluctuation.

ABSTRACT: Adipocytes specialized in the storage of energy as fat are among the most caveolae-enriched cell types. Loss of caveolae produces lipodystrophic diabetes in humans, which cannot be reversed by endothelial rescue of caveolin expression in mice, indicating major importance of adipocyte caveolae. However, how caveolae participate in fat cell functions is poorly understood. We investigated dynamic conditions of lipid store fluctuations and demonstrate reciprocal regulation of caveolae density and fat cell lipid droplet storage. We identified caveolin-1 expression as a crucial step in adipose cell lines and in mice to raise the density of caveolae, to increase adipocyte ability to accommodate larger lipid droplets, and to promote cell expansion by increased glucose utilization. In human subject

SUBMITTER: Briand N 

PROVIDER: S-EPMC4238006 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature