Characteristics and long-term follow-up of participants with peripheral arterial disease during ALLHAT.

ABSTRACT:

Background

Hypertension is a major risk factor for peripheral artery disease (PAD). Little is known about relative efficacy of antihypertensive treatments for preventing PAD.

Objectives

To compare, by randomized treatment groups, hospitalized or revascularized PAD rates and subsequent morbidity and mortality among participants in the Antihypertensive and Lipid-Lower Treatment to Prevent Heart Attack Trial (ALLHAT).

Design

Randomized, double-blind, active-control trial in high-risk hypertensive participants.

Participants

Eight hundred thirty participants with specified secondary outcome of lower extremity PAD events during the randomized phase of ALLHAT.

Interventions/events

In-trial PAD events were reported during ALLHAT (1994-2002). Post-trial mortality

SUBMITTER: Piller LB 

PROVIDER: S-EPMC4238201 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature