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Merging gold and organocatalysis: a facile asymmetric synthesis of annulated pyrroles.

ABSTRACT: The combination of cinchona-alkaloid-derived primary amine and Au(I) -phosphine catalysts allowed the selective C-H functionalization of two adjacent carbon atoms of pyrroles under mild reaction conditions. This sequential dual activation provides seven-membered-ring-annulated pyrrole derivatives in excellent yields and enantioselectivities.

SUBMITTER: Hack D

PROVIDER: S-EPMC4238261 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature

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Merging gold and organocatalysis: a facile asymmetric synthesis of annulated pyrroles.

Hack Daniel D Loh Charles C J CC Hartmann Jan M JM Raabe Gerhard G Enders Dieter D

Chemistry (Weinheim an der Bergstrasse, Germany) 20140303 14

The combination of cinchona-alkaloid-derived primary amine and Au(I) -phosphine catalysts allowed the selective C-H functionalization of two adjacent carbon atoms of pyrroles under mild reaction conditions. This sequential dual activation provides seven-membered-ring-annulated pyrrole derivatives in excellent yields and enantioselectivities. ...[more]

PMID: 24590817

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