Kinetic studies of Candida parapsilosis phagocytosis by macrophages and detection of intracellular survival mechanisms.

ABSTRACT: Even though the number of Candida infections due to non-albicans species like C. parapsilosis has been increasing, little is known about their pathomechanisms. Certain aspects of C. parapsilosis and host interactions have already been investigated; however we lack information about the innate cellular responses toward this species. The aim of our project was to dissect and compare the phagocytosis of C. parapsilosis to C. albicans and to another Candida species C. glabrata by murine and human macrophages by live cell video microscopy. We broke down the phagocytic process into three stages: macrophage migration, engulfment of fungal cells and host cell killing after the uptake. Our results showed increased macrophage migration toward C. parapsilosis and we observed differences during the en

SUBMITTER: Toth R 

PROVIDER: S-EPMC4238376 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature