CYP2E1 gene rs6413420 polymorphism was first found in the Bouyei ethnic group of China.

ABSTRACT:

Background

China is a multinational country. The relationship between gene polymorphisms of xenobiotic metabolizing enzymes and national ethnicity has not previously investigated among Chinese people. The aim of this study was to investigate distributions of CYP1A1 and CYP2E1 gene polymorphisms in five ethnic groups of China.

Methods

829 blood samples were collected from five ethnic groups (Han, Shui, Miao, Zhuang, Bouyei). Taqman-MGB probe was used in Real-time PCR to test the gene polymorphisms of CYP1A1 (rs1048943 and rs4646903) and CYP2E1 (rs2031920 and rs6413420). We further validate the SNP genotyping results through DNA sequencing.

Results

The genotype distribution of all four SNPs was in accordance with Hardy-Weinberg equilibrium except the genotype distributi

SUBMITTER: Liu W 

PROVIDER: S-EPMC4238488 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature