Genetically low vitamin D concentrations and increased mortality: Mendelian randomisation analysis in three large cohorts.

ABSTRACT:

Objective

To test the hypothesis that genetically low 25-hydroxyvitamin D concentrations are associated with increased mortality.

Design

Mendelian randomisation analysis.

Setting

Copenhagen City Heart Study, Copenhagen General Population Study, and Copenhagen Ischemic Heart Disease Study.

Participants

95 766 white participants of Danish descent from three cohorts, with median follow-up times of 19.1, 5.8, and 7.9 years, genotyped for genetic variants in DHCR7 and CYP2R1 affecting plasma 25-hydroxyvitamin D concentrations; 35 334 also had plasma 25-hydroxyvitamin D measurements. Participants were followed from study entry through 2013, during which time 10 349 died.

Main outcome measures

All cause mortality and cause specific mortality, adjusted for commo

SUBMITTER: Afzal S 

PROVIDER: S-EPMC4238742 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature