Fibrinogen and platelet contributions to clot formation: implications for trauma resuscitation and thromboprophylaxis.

ABSTRACT:

Background

Thromboelastography (TEG) is used to diagnose perturbations in clot formation and lysis that are characteristic of acute traumatic coagulopathy. With novel functional fibrinogen (FF) TEG, fibrin- and platelet-based contributions to clot formation can be elucidated to tailor resuscitation and thromboprophylaxis. We sought to describe the longitudinal contributions of fibrinogen and platelets to clot strength after injury, hypothesizing that low levels of FF and a low contribution of fibrinogen to clot strength on admission would be associated with coagulopathy, increased transfusion requirements, and worse outcomes.

Methods

A total of 603 longitudinal plasma samples were prospectively collected from 251 critically injured patients at a single Level 1 trauma center

SUBMITTER: Kornblith LZ 

PROVIDER: S-EPMC4238905 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature