Approaches to refining estimates of global burden and economics of dengue.

ABSTRACT: Dengue presents a formidable and growing global economic and disease burden, with around half the world's population estimated to be at risk of infection. There is wide variation and substantial uncertainty in current estimates of dengue disease burden and, consequently, on economic burden estimates. Dengue disease varies across time, geography and persons affected. Variations in the transmission of four different viruses and interactions among vector density and host's immune status, age, pre-existing medical conditions, all contribute to the disease's complexity. This systematic review aims to identify and examine estimates of dengue disease burden and costs, discuss major sources of uncertainty, and suggest next steps to improve estimates. Economic analysis of dengue is mainly concerned

SUBMITTER: Shepard DS 

PROVIDER: S-EPMC4238988 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature