Trypanocide treatment of women infected with Trypanosoma cruzi and its effect on preventing congenital Chagas.

ABSTRACT: With the control of the vectorial and transfusional routes of infection with Trypanosoma cruzi, congenital transmission has become an important source of new cases. This study evaluated the efficacy of trypanocidal therapy to prevent congenital Chagas disease and compared the clinical and serological evolution between treated and untreated infected mothers. We conducted a multicenter, observational study on a cohort of mothers infected with T. cruzi, with and without trypanocidal treatment before pregnancy. Their children were studied to detect congenital infection. Among 354 "chronically infected mother-biological child" pairs, 132 were treated women and 222 were untreated women. Among the children born to untreated women, we detected 34 infected with T. cruzi (15.3%), whose only antecede

SUBMITTER: Fabbro DL 

PROVIDER: S-EPMC4239005 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature