Characterizing the structure of lipodisq nanoparticles for membrane protein spectroscopic studies.

ABSTRACT: Membrane protein spectroscopic studies are challenging due to the difficulty introduced in preparing homogenous and functional hydrophobic proteins incorporated into a lipid bilayer system. Traditional membrane mimics such as micelles or liposomes have proved to be powerful in solubilizing membrane proteins for biophysical studies, however, several drawbacks have limited their applications. Recently, a nanosized complex termed lipodisq nanoparticles was utilized as an alternative membrane mimic to overcome these caveats by providing a homogeneous lipid bilayer environment. Despite all the benefits that lipodisq nanoparticles could provide to enhance the biophysical studies of membrane proteins, structural characterization in different lipid compositions that closely mimic the native membra

SUBMITTER: Zhang R 

PROVIDER: S-EPMC4239197 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature