Assessing effects of cholera vaccination in the presence of interference.

ABSTRACT: Interference occurs when the treatment of one person affects the outcome of another. For example, in infectious diseases, whether one individual is vaccinated may affect whether another individual becomes infected or develops disease. Quantifying such indirect (or spillover) effects of vaccination could have important public health or policy implications. In this article we use recently developed inverse-probability weighted (IPW) estimators of treatment effects in the presence of interference to analyze an individually-randomized, placebo-controlled trial of cholera vaccination that targeted 121,982 individuals in Matlab, Bangladesh. Because these IPW estimators have not been employed previously, a simulation study was also conducted to assess the empirical behavior of the estimators in s

SUBMITTER: Perez-Heydrich C 

PROVIDER: S-EPMC4239215 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature