Biosynthesis of β-carotene in engineered E. coli using the MEP and MVA pathways.

ABSTRACT:

Background

β-carotene is a carotenoid compound that has been widely used not only in the industrial production of pharmaceuticals but also as nutraceuticals, animal feed additives, functional cosmetics, and food colorants. Currently, more than 90% of commercial β-carotene is produced by chemical synthesis. Due to the growing public concern over food safety, the use of chemically synthesized β-carotene as food additives or functional cosmetic agents has been severely controlled in recent years. This has reignited the enthusiasm for seeking natural β-carotene in large-scale fermentative production by microorganisms.

Results

To increase β-carotene production by improving the isopentenyl pyrophosphate (IPP) and geranyl diphospate (GPP) concentration in the cell, the optimized ME

SUBMITTER: Yang J 

PROVIDER: S-EPMC4239400 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature