Vesicles derived via AP-3-dependent recycling contribute to asynchronous release and influence information transfer.

ABSTRACT: Action potentials trigger synchronous and asynchronous neurotransmitter release. Temporal properties of both types of release could be altered in an activity-dependent manner. While the effects of activity-dependent changes in synchronous release on postsynaptic signal integration have been studied, the contribution of asynchronous release to information transfer during natural stimulus patterns is unknown. Here we find that during trains of stimulations, asynchronous release contributes to the precision of action potential firing. Our data show that this form of release is selectively diminished in AP-3b2 KO animals, which lack functional neuronal AP-3, an adaptor protein regulating vesicle formation from endosomes generated during bulk endocytosis. We find that in the absence of neuronal

SUBMITTER: Evstratova A 

PROVIDER: S-EPMC4239664 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature