Responsiveness of cardiometabolic-related microbiota to diet is influenced by host genetics.

ABSTRACT: Intestinal microbial community structure is driven by host genetics in addition to environmental factors such as diet. In comparison with environmental influences, the effect of host genetics on intestinal microbiota, and how host-driven differences alter host metabolism is unclear. Additionally, the interaction between host genetics and diet, and the impact on the intestinal microbiome and possible down-stream effect on host metabolism is not fully understood, but represents another aspects of inter-individual variation in disease risk. The objectives of this study were to investigate how diet and genetic background shape microbial communities, and how these diet- and genetic-driven microbial differences relate to cardiometabolic phenotypes. To determine these effects, we used the 8 proge

SUBMITTER: O'Connor A 

PROVIDER: S-EPMC4239785 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature