Imaging prodromal Parkinson disease: the Parkinson Associated Risk Syndrome Study.

ABSTRACT:

Objectives

The purpose of this study is to evaluate the relative risk of abnormal dopamine transporter (DAT) imaging for subjects with and without hyposmia and the feasibility of acquiring a large, community-based, 2-tiered biomarker assessment strategy to detect prodromal Parkinson disease (PD).

Methods

In this observational study, individuals without a diagnosis of PD, recruited through 16 movement disorder clinics, underwent tier 1 assessments (olfactory testing, questionnaires). Tier 2 assessments (neurologic examination, DAT imaging, and other biomarker assessments) were completed by 303 subjects. The main outcome of the study is to compare age-expected [(123)I]β-CIT striatal binding ratio in hyposmic and normosmic subjects.

Results

Tier 1 assessments were mailed

SUBMITTER: Jennings D 

PROVIDER: S-EPMC4239830 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature